Underlying occurrence of other autoimmune diseases like type 1 diabetes or rheumatoid arthritis. The antibody associated with Graves’ disease is known as TRAb or thyrotropin receptor. Diabetic dermopathy (pictures 1) is a complication caused by high level of blood sugar, the reason for which is not studied in a proper way. Even though it can affect people of all ages, it is more common in women and those younger than 40 years old. Other treatments included antibiotics for local infection, tretinoin, “hot cream,” salicylic acid, ammonium lactate lotion, and vacuum pump therapy for swelling. Patients seen before 1989, who were subjects of a previous report (1), are included in the present study.

Over time, secondary hyperkeratosis may occur, which may become verruciform. Thus, if patients with severe dermopathy are those receiving topical corticosteroids, compressive dressings, or intralesional corticosteroid injections, the long-term efficacy of these treatments is difficult to evaluate from the present study because they cannot be compared with the no-therapy group. Patients who were treated were slightly older and were more likely to be male, although neither variable approached statistical significance (Table 1). Mild cases of dermopathy can be observed, or they can be treated with local corticosteroids if there is cosmetic concern or local discomfort. This increased deposition apparently results from increased fibroblast stimulation, but the cause of this stimulation, although of autoimmune origin, is not yet clear.

Generally, thyrotoxicosis develops first, followed by ophthalmopathy and finally dermopathy in patients who have all of these manifestations (1, 23).

Pretibial myxedema (myxoedema (UK), also known as Graves' dermopathy, thyroid dermopathy, Jadassohn-Dösseker disease or Myxoedema tuberosum) is an infiltrative dermopathy, resulting as a rare complication of Graves' disease, with an incidence rate of about 1-5%. Graves Disease Treatment. In the present study, 3% of our patients did not have a diagnosis of clinical ophthalmopathy.

Detection, cellular localization, and modulation of heat shock proteins in cultured fibroblasts from patients with extrathyroidal manifestations of Graves’ disease.

D, Elephantiasic form. These manifestations, as mentioned previously, are most commonly found in the pretibial area, a fact that several researchers have attempted to explain. There was a high rate of rehabilitative eye surgery in the cohort, which included 46 eye muscle, 26 eyelid, 44 transantral orbital decompression, and 3 transfrontal decompression operations. Mucin staining demonstrated abundant diffuse mucin within the dermal fenestrations as large amounts of glycosaminoglycans (GAG) diffusely dispersed in the reticular part of the dermis. Among patients who did not receive treatment for PTM, no variable was a statistically significant predictor of final outcome status. The beneficial effect of topical corticosteroid therapy on long-term remission rates remains to be determined. Of the remaining 138 patients, 110 returned surveys (80% response rate), 3 refused participation, 14 could not be contacted, and 11 had no response or had other exclusions. Effect of plasmapheresis and steroid treatment on thyrotropin binding inhibitory immunoglobulins in a patient with exophthalmos and a patient with pretibial myxedema. Baseline clinical characteristics of patients who received therapy for dermopathy at any time compared with patients who never received therapy. The treatment of dermopathy is usually symptomatic. Signs and symptoms. See our safe care and visitor guidelines, plus trusted coronavirus information. The results of our study were consistent with this pattern, with 83% of patients having had thyroid disease before the development of dermopathy and 72% having had ophthalmopathy before PTM. Is it a rare condition? Eighty-two (46.1%) of the 178 patients did not receive any topical corticosteroid treatments, 81 (45.5%) received one course of treatment, 12 (6.7%) received two courses, and 3 (1.7%) received three or more courses.

The majority of patients with dermopathy had ophthalmopathy (97.0%). With further protrusion of the eyes, double vision and vision loss may occur. Thus, increased deposition of GAG may occur throughout the body without clinical manifestations. Histologic confirmation of diagnosis was available in 104 patients (58.4%). The ophthalmopathy tends to worsen with smoking.

Combined percentage of patients who had partial or complete remission according to treatment group (Kaplan-Meier method). In our study, 10 patients had such a problem, and 21 complained of local discomfort. Patients who received therapy were generally treated with topical corticosteroids under occlusion or compressive dressings. The lesions were occasionally indurated and the hair follicles prominent so that the lesions had an orange peel (peau d’orange) or pig skin appearance and texture. Mayo Clinic College of Medicine and Science, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, DS00181 AN00605 IM02348 ans7 myxedemathu jpg, Advertising and sponsorship opportunities. All rights reserved. Should Graves’ disease be considered a collagen disorder of the thyroid, skeletal muscle and connective tissue? In a multivariate logistic regression analysis using a stepwise selection procedure, the only predictor of improved outcome in the treatment group was a history of transantral orbital decompression and eye muscle surgery for ophthalmopathy (Table 4). Hyperpigmentation and hyperkeratosis were also present in some cases, as was hyperhidrosis. Evidence for benefits of systemic or local octreotide therapy is inadequate. Optimum local corticosteroid therapy is usually 4–8 wk and can be extended to 1 yr, depending on response. In fact, localized myxedema has been documented outside the pretibial region. Twenty-one patients (11.8%) received compressive dressing treatment. In our study, we had a 47.9% partial or complete remission rate among more severe cases treated with corticosteroids at any time, compared with a 55.6% partial or complete remission rate among patients with milder disease who did not receive any treatment. Surgery to remove the thyroid gland. No statistically significant difference was found between treated and untreated groups in the proportion of patients having combined complete plus partial remission (P = 0.30) as their final outcome. The average age for female patients was 52.9 yr (range 14.3–79.6) and for male patients 54.1 yr (range 31.8–75.7 yr). Smoking. Doctors may also refer to the condition as pretibial myxedema.

Successful treatment of chronic skin diseases with clobetasol propionate and a hydrocolloid occlusive dressing. Forty-two patients (23.6%) had been treated with a single course of antithyroid agents, and one patient with 2 courses. Endocrinologists usually made the initial diagnosis, and 116 patients (65.2%) received diagnostic confirmation by a dermatologist.

This could be related to the severity of the treated cases, and we cannot conclude that treatment in severe cases does not improve long-term outcome. It occasionally occurs in non-thyrotoxic Graves' disease, Hashimoto's thyroiditis, and stasis dermatitis. Pretibial myxedema is almost always preceded by the ocular signs found in Graves' disease. Dermopathy was classified into one of the following four forms: nonpitting edema accompanied by typical skin color changes, plaque, nodular, or elephantiasic (Fig. It forms the third component of the classical triad of Graves' disease (goiter, ophthalmopathy, pretibial myxedema). It can be in the form of diabetic sores (pictures 2) or various dermal diseases. Patients were also asked to indicate whether they were taking thyroid hormone replacement therapy. Many call it shin spots because of its location. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Treatment of the affected skin may also include: Even with successful treatment of the underlying Graves' disease, you may still have cosmetic issues and have a hard time getting shoes to fit well. Thirty-one cases of acropachy were diagnosed (17.4%). The clinical form of PTM was nonpitting edema in 77 (43.3%), plaque in 48 (27.0%), nodular in 33 (18.5%), elephantiasic in 5 (2.8%), and unclassifiable and/or unknown in 15 (8.4%). Elastic stains will reveal a reduction in elastic tissue. Werner & Ingbar’s the thyroid: a fundamental and clinical text, ed 8. Wortsman et al. It may also cause compression or occlusion of small local lymphatics and thereby increase the dermal edema (4). Cases have been reported involving the shoulders, upper back, upper extremities, and pinnae (22).